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Literature summary extracted from

  • Ho, K.L.; Ma, L.; Cheung, S.; Manhas, S.; Fang, N.; Wang, K.; Young, B.; Loewen, C.; Mayor, T.; Measday, V.
    A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition (2015), PLoS Genet., 11, e1005109.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.49 securin
-
 Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.49 200000
-
 x * 200000, GFP-tagged enzyme, SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.49 cohesin + H2O Saccharomyces cerevisiae
-
 ?
-
 ?
3.4.22.49 additional information Saccharomyces cerevisiae the enzyme interacts with Ty1-IN and does not affect the processing of the TyA-TyB polypeptide ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.49 Saccharomyces cerevisiae Q03018
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.49 cohesin + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
3.4.22.49 additional information the enzyme interacts with Ty1-IN and does not affect the processing of the TyA-TyB polypeptide Saccharomyces cerevisiae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.49 ? x * 200000, GFP-tagged enzyme, SDS-PAGE Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
3.4.22.49 Esp1
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
3.4.22.49 physiological function separase is required at the onset of anaphase to cleave cohesin and thereby enable sister chromatid separation. The enzyme also promotes release of the Cdc14 phosphatase from the nucleolus to enable mitotic exit. The enzyme serves two roles to mediate Ty1 transposition, one to remove cohesin and the second to target Ty1-IN to chromatin Saccharomyces cerevisiae